The many modules of Numera

Multiplexer module

This module communicates with and samples up to 16 bioreactors, with small 2-4ml volumes taken to ensure minimal impact on process yields. The modules’ pinch valves, as well as ability to self-clean with ethanol ensure sterility between samples, enabling reliable and repeatable results.

Routing module

Located centrally for maximum flexibility, the routing module transfers samples to and from any other Numera module, up to 4 third party analysers, as well as an HPLC connected to the system. Each sample can be routed individually depending on it’s purpose, with the autonomous routing module facilitating movement while minimising the risk of errors and contamination.

Dilution module

The purpose of the dilution module is to prepare samples prior to storage or analysis. It is able to dilute with a high degree of precision from 1:2 – 1:25 times, as well as mix, set reaction times and otherwise prepare samples with additional reagents before they are moved on by the routing module.

Filtration module

The filtration module is used to remove cell debris or other contaminants before samples are sent to the autosampler for either storage or analysis. Numera utilises a unique tape-filter technology which ensures each sample is put through a new and unsoiled filter; minimising risk of contamination without needing to swap out filters manually between samples. Filters are available in sizes ranging from 0.22-1.2 µm, making the suitable for a wide spectrum of products.

Autosampler module

After filtration, samples are sent to the stand-alone autosampler module, which stores 48-320 samples in a chilled environment, in the form of deep-well plates or vials. From here, samples can be taken for analysis on an offline analyser or send to a third party HPLC. Manually drawn-off samples can also be deposited here, either for storage or preparation and analysis by Numera.

Control module

Sample planning and execution is directed and interfaced with via the control module, which uses Securecell’s innovative Lucullus process information & management software. Once sampling and analysis has occurred, Numera can feed the resulting data back into Lucullus, which can then align it with the result of your process data.